Clinical Studies

Abstracts are presented below for clinical studies on Jatamansi.

  • Botanical Name: Nardostachys Jatamansi

  • Ayurvedic Name: Jatamansi

  • Common Name: Jatamansi

Nardostachys Jatamansi

Plant Phytonutrient Profile


1: J Ethnopharmacol. 2007 Jan 19;109(2):359-63. Epub 2006 Aug 4.

Screening of selected Indian medicinal plants for acetylcholinesterase
inhibitory activity.

Vinutha B, Prashanth D, Salma K, Sreeja SL, Pratiti D, Padmaja R, Radhika S,
Amit A, Venkateshwarlu K, Deepak M.

Department of Pharmacognosy, Al-Ameen College of Pharmacy, Hosur Road,
Bangalore, India.

Seventy-six plant extracts including methanolic and successive water extracts
from 37 Indian medicinal plants were investigated for acetylcholinesterase
(AChE) inhibitory activity (in vitro). Results indicated that methanolic
extracts to be more active than water extracts. The potent AChE inhibiting
methanolic plant extracts included Withania somnifera (root), Semecarpus
anacardium (stem bark), Embelia ribes (Root), Tinospora cordifolia (stem), Ficus
religiosa (stem bark) and Nardostachys jatamansi (rhizome). The IC(50) values
obtained for these extracts were 33.38, 16.74, 23.04, 38.36, 73.69 and
47.21mug/ml, respectively. These results partly substantiate the traditional use
of these herbs for improvement of cognition.

PMID: 16950584 [PubMed - in process]

2: J Ethnopharmacol. 2006 Sep 19;107(2):182-8. Epub 2006 Mar 27.

Search for antibacterial and antifungal agents from selected Indian medicinal
plants.

Kumar VP, Chauhan NS, Padh H, Rajani M.

B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre,
Thaltej, Ahmedabad 380054, India.

A series of 61 Indian medicinal plants belonging to 33 different families used
in various infectious disorders, were screened for their antimicrobial
properties. Screening was carried out at 1000 and 500 microg/ml concentrations
by agar dilution method against Bacillus cereus var mycoides, Bacillus pumilus,
Bacillus subtilis, Bordetella bronchiseptica, Micrococcus luteus, Staphylococcus
aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae,
Pseudomonas aeruginosa, Streptococcus faecalis, Candida albicans, Aspergillus
niger and Saccharomyces cerevisiae. Twenty-eight plant extracts showed activity
against at least one of the test organisms used in the screening. On the basis
of the results obtained, we conclude that the crude extracts of Dorema
ammoniacum, Sphaeranthus indicus, Dracaena cinnabari, Mallotus philippinensis,
Jatropha gossypifolia, Aristolochia indica, Lantana camara, Nardostachys
jatamansi, Randia dumetorum and Cassia fistula exhibited significant
antimicrobial activity and properties that support folkloric use in the
treatment of some diseases as broad-spectrum antimicrobial agents. This probably
explains the use of these plants by the indigenous people against a number of
infections.

Publication Types:
Research Support, Non-U.S. Gov't

PMID: 16678369 [PubMed - indexed for MEDLINE]

3: J Med Food. 2006 Spring;9(1):113-8.

Nardostachys jatamansi improves learning and memory in mice.

Joshi H, Parle M.

Department of Pharmacognosy, SET's College of Pharmacy, Dharwad, Karnataka,
India.

Cure of cognitive disorders such as amnesia, attention deficit, and Alzheimer's
disease is still far from being realized in the field of medicine. Nootropic
agents such as piracetam, aniracetam, and choline esterase inhibitors like
donepezil are being used for improving memory, mood, and behavior, but the
resulting side effects associated with these agents have made their
applicability limited. In Ayurveda, the roots of Nardostachys jatamansi have
been clinically employed for their anti-ischemic, antioxidant, anticonvulsant,
and neuroprotective activities. The present study was undertaken to assess the
potential of N. jatmansi as a memory enhancer. The elevated plus maze and the
passive avoidance paradigm were employed to evaluate learning and memory
parameters. Three doses (50, 100, and 200 mg/kg, p.o.) of an ethanolic extract
of N. jatamansi were administered for 8 successive days to both young and aged
mice. The 200 mg/kg dose of N. jatmansi ethanolic extract significantly improved
learning and memory in young mice and also reversed the amnesia induced by
diazepam (1 mg/kg, i.p.) and scopolamine (0.4 mg/kg, i.p.). Furthermore, it also
reversed aging-induced amnesia due to natural aging of mice. As
scopolamine-induced amnesia was reversed, it is possible that the memory
improvement may be because of facilitation of cholinergic transmission in the
brain. Hence, N. jatmansi might prove to be a useful memory restorative agent in
the treatment of dementia seen in elderly persons. The underlying mechanism of
action can be attributed to its antioxidant property.

PMID: 16579738 [PubMed - indexed for MEDLINE]

4: Pharmacol Biochem Behav. 2006 Jan;83(1):150-60. Epub 2006 Feb 28.

Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced parkinsonism
in rats: behavioral, neurochemical, and immunohistochemical studies.

Ahmad M, Yousuf S, Khan MB, Hoda MN, Ahmad AS, Ansari MA, Ishrat T, Agrawal AK,
Islam F.

Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology,
Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India.
mahmad7@jhmi.edu

Parkinson's disease (PD) is one of the commonest neurodegenerative diseases, and
oxidative stress has been evidenced to play a vital role in its causation. In
the present study, we evaluated whether ethanolic extract of Nardostachys
jatamansi roots (ENj), an antioxidant and enhancer of biogenic amines, can slow
the neuronal injury in a 6-OHDA-rat model of Parkinson's. Rats were treated with
200, 400, and 600 mg/kg body weight of ENj for 3 weeks. On day 21, 2 microl of
6-OHDA (12 microg in 0.01% in ascorbic acid-saline) was infused into the right
striatum, while the sham-operated group received 2 microl of vehicle. Three
weeks after the 6-OHDA injection, the rats were tested for neurobehavioural
activity and were sacrificed after 6 weeks for the estimation of lipid
peroxidation, reduced glutathione content, the activities of
glutathione-S-transferase, glutathione reductase, glutathione peroxidase,
superoxide dismutase and catalase, quantification of catecholamines,
dopaminergic D2 receptor binding and tyrosine hydroxylase expression. The
increase in drug-induced rotations and deficits in locomotor activity and
muscular coordination due to 6-OHDA injections were significantly and
dose-dependently restored by ENj. Lesioning was followed by an increased lipid
peroxidation and significant depletion of reduced glutathione content in the
substantia nigra, which was prevented with ENj pretreatment. The activities of
glutathione-dependent enzymes, catalase and superoxide dismutase in striatum,
which were reduced significantly by lesioning, were dose-dependently restored by
ENj. A significant decrease in the level of dopamine and its metabolites and an
increase in the number of dopaminergic D2 receptors in striatum were observed
after 6-OHDA injection, and both were significantly recovered following ENj
treatment. All of these results were exhibited by an increased density of
tyrosine hydroxylase immunoreactive (TH-IR) fibers in the ipsilateral striatum
of the lesioned rats following treatment with ENj; 6-OHDA injection had induced
almost a complete loss of TH-IR fibers. This study indicates that the extract of
Jatamansi might be helpful in attenuating Parkinsonism.

PMID: 16500697 [PubMed - indexed for MEDLINE]

5: J Pharm Pharmacol. 2006 Feb;58(2):257-62.

Protective effect of Nardostachys jatamansi on oxidative injury and cellular
abnormalities during doxorubicin-induced cardiac damage in rats.

Subashini R, Yogeeta S, Gnanapragasam A, Devaki T.

Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600
025, Tamil Nadu, India.

Nardostachys jatamansi is a medicinally important herb of Indian origin. It has
been used for centuries in the Ayurvedic and Unani systems of medicine for the
treatment of various ailments. We have evaluated the effect of N. jatamansi
(rhizomes) on the biochemical changes, tissue peroxidative damage and abnormal
antioxidant levels in doxorubicin (adriamycin)-induced cardiac damage.
Preliminary studies on the effect of the graded dose of extract showed that 500
mg kg(-1) orally for seven days was found to be optimum and hence all further
study was carried out with this particular dose. Rats administered doxorubicin
(15 mg kg(-1), i.p.) showed myocardial damage that was manifested by the
elevation of serum marker enzymes (lactate dehydrogenase, creatine
phosphokinase, aspartate aminotransaminase and alanine aminotransaminase). The
animals showed significant changes in the antioxidant enzymes (superoxide
dismutase, catalase, glutathione peroxidase and glutathione-S-transferase) and
lipid peroxidation levels. Pretreatment with N. jatamansi extract significantly
prevented these alterations and restored the enzyme activity and lipid peroxides
to near normal levels. Restoration of cellular normality accredits the N.
jatamansi with a cytoprotective role in doxorubicin-induced cardiac damage.

PMID: 16451755 [PubMed - indexed for MEDLINE]

6: J Ethnopharmacol. 2005 Dec 1;102(3):351-6. Epub 2005 Aug 10.

Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats.

Rao VS, Rao A, Karanth KS.

Department of Botany, 220 Bartram Hall, University of Florida, Gainesville,
32611, USA. vsrao@ufl.edu

Ethanol extract of the roots of Nardostachys jatamansi DC. (Valerianaceae) was
studied for its anticonvulsant activity and neurotoxicity, alone and in
combination with phenytoin in rats. The results demonstrated a significant
increase in the seizure threshold by Nardostachys jatamansi root extract against
maximal electroshock seizure (MES) model as indicated by a decrease in the
extension/flexion (E/F) ratio. However, the extract was ineffective against
pentylenetetrazole (PTZ)-induced seizures. Nardostachys jatamansi root extract
also showed minimal neurotoxicity against rotarod test at doses that increased
the seizure threshold. Further, pretreatment of rats with phenytoin at a dose of
12.5, 25, 50 and 75 mg/kg in combination with 50mg/kg of Nardostachys jatamansi
root extract resulted in a significant increase in the protective index (PI) of
phenytoin from 3.63 to 13.18. The dose response studies of phenytoin alone and
in combination with Nardostachys jatamansi extract on the serum levels of
phenytoin clearly demonstrated the synergistic action of both the drugs.

PMID: 16095854 [PubMed - indexed for MEDLINE]

7: Pharmacol Biochem Behav. 2003 Jan;74(2):481-6.

Protective effect of Nardostachys jatamansi in rat cerebral ischemia.

Salim S, Ahmad M, Zafar KS, Ahmad AS, Islam F.

Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology,
Jamia Hamdard University, Hamdard Nagar, New Delhi 110062, India.
fislam2001@yahoo.co.in

The protective effect of Nardostachys jatamansi (NJ) on neurobehavioral
activities, thiobarbituric acid reactive substance (TBARS), reduced glutathione
(GSH), thiol group, catalase and sodium-potassium ATPase activities was studied
in middle cerebral artery (MCA) occlusion model of acute cerebral ischemia in
rats. The right MCA of male Wistar rats was occluded for 2 h using intraluminal
4-0 monofilament and reperfusion was allowed for 22 h. MCA occlusion caused
significant depletion in the contents of glutathione and thiol group and a
significant elevation in the level of TBARS. The activities of Na(+)K(+) ATPase
and catalase were decreased significantly by MCA occlusion. The neurobehavioral
activities (spontaneous motor activity and motor coordination) were also
decreased significantly in MCA occlusion group. All the alternations induced by
ischemia were significantly attenuated by 15 days pretreatment of NJ (250 mg/kg
po) and correlated well with histopathology by decreasing the neuronal cell
death following MCA occlusion and reperfusion. The study provides first evidence
of effectiveness of NJ in focal ischemia most probably by virtue of its
antioxidant property.

Publication Types:
Research Support, Non-U.S. Gov't

PMID: 12479970 [PubMed - indexed for MEDLINE]

8: J Nat Prod. 2000 Nov;63(11):1531-3.

Structure and stereochemistry of nardostachysin, a new terpenoid ester
constituent of the rhizomes of Nardostachys jatamansi.

Chatterjee A, Basak B, Saha M, Dutta U, Mukhopadhyay C, Banerji J, Konda Y,
Harigaya Y.

UGC Centre of Advanced Studies on Natural Products, Department of Chemistry,
Calcutta University, 92, Acharya Prafulla Chandra Road, Calcutta 700 009, India.

The structure and stereochemistry of a new terpenoid ester, nardostachysin (1),
isolated from the rhizomes of Nardostachys jatamansi, were established as the
7',8'-dihydroxy-4'-methylene hexahydrocyclopenta[c]pyran-1'-one-8'-methyl ester
of 7, 9-guaiadien-14-oic acid, by spectral and chemical studies.

Publication Types:
Research Support, Non-U.S. Gov't

PMID: 11087600 [PubMed - indexed for MEDLINE]

9: J Ethnopharmacol. 2000 Aug;71(3):359-63.

Nardostachys jatamansi protects against liver damage induced by thioacetamide in
rats.

Ali S, Ansari KA, Jafry MA, Kabeer H, Diwakar G.

Department of Biochemistry, Faculty of Science, Hamdard University, -1100 62,
New Delhi, India.

Nardostachys jatamansi is a medically important herb of Indian origin used for
centuries in Ayurvedic and Unani systems of medicine for the treatment of
various ailments. In the present paper, a 50% ethanolic extract of the rhizomes
of N. jatamansi is shown to possess hepatoprotective activity. Pretreatment of
rats with the extract (800 mg/kg body wt, orally) for three consecutive days
significantly ameliorated the liver damage in rats exposed to the hepatotoxic
compound thioacetamide. Elevated levels of serum transaminases
(aminotransferases) and alkaline phosphatase, observed in thioacetamide alone
treated group of animals, were significantly lowered in N. jatamansi pretreated
rats. Pretreatment of the animals with the extract also resulted in an increase
in survival in rats intoxicated with LD90 dose of the hepatotoxic drug.

PMID: 10940571 [PubMed - indexed for MEDLINE]

10: Planta Med. 1994 Apr;60(2):114-7.

Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids
in the rat brain.

Prabhu V, Karanth KS, Rao A.

Department of Biochemistry, Kasturba Medical College, Karnataka, India.

The effect of acute and subchronic administration of an alcoholic extract of the
roots of Nardostachys jatamansi on norepinephrine (NE), dopamine (DA), serotonin
(5-HT), 5-hydroxyindoleacetic acid (5-HIAA), gamma-aminobutyric acid (GABA), and
taurine were studied in male albino Wistar rats. The acute oral administration
of the extract did not change the level of NE and DA but resulted in a
significant increase in the level of 5-HT and 5-HIAA. A significant increase in
the level of GABA and taurine was observed in the drug-treated groups when
compared to the controls. A 15-day treatment resulted in a significant increase
in the levels of NE, DA, 5-HT, 5-HIAA, and GABA. These data indicate that the
alcoholic extract of the roots of N. jatamansi causes an overall increase in the
levels of central monoamines and inhibitory amino acids.

PMID: 8202559 [PubMed - indexed for MEDLINE]

11: Planta Med. 1991 Jun;57(3):282-3.

Jatamols A and B: Sesquiterpenoids of Nardostachys jatamansi Roots1.

Bagchi A, Oshima Y, Hikino H.

Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan.

From the roots and rhizomes of NARDOSTACHYS JATAMANSI, two new eudesmanes
jatamols A and B were isolated, and their structures were determined by spectral
analysis and chemical evidence.

PMID: 17226161 [PubMed - in process]

12: Planta Med. 1991 Feb;57(1):96-7.

Neolignans and Lignans of Nardostachys jatamansi Roots1.

Bagchi A, Oshima Y, Hikino H.

Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan.

PMID: 17226134 [PubMed - in process]

13: Indian J Physiol Pharmacol. 1988 Oct-Dec;32(4):299-304.

Hypolipidaemic effects of Curcuma longa L and Nardostachys jatamansi, DC in
triton-induced hyperlipidaemic rats.

Dixit VP, Jain P, Joshi SC.

Department of Zoology, University of Rajasthan, Jaipur.

Fifty per cent ethanolic extract of Curcuma longa (tuber) and Nardostachys
jatamansi (whole plant) feeding elevates HDL-cholesterol/total cholesterol
ratio. The extracts also caused a significant reduction in the ratio of total
cholesterol/phospholipids. Curcuma longa exhibited better cholesterol and
triglyceride lowering activity [Ch = -85%; Tg = -88%] as compared to N.
jatamansi in triton-induced hyperlipidaemic rats. In view of the protective
action of HDL against heart disease and atherogenecity, C. longa consumption is
recommended.

PMID: 3215683 [PubMed - indexed for MEDLINE]

14: Zentralbl Bakteriol Naturwiss. 1978;133(7-8):723-5.

Efficacy of some essential oils and their constituents on few ubiquitous molds.

Sarbhoy AK, Varshney JL, Maheshwari ML, Saxena DB.

Six essential oils of Mentha arvensis, Mentha piperita, Anethum sowa, Cymbopogon
winterianus, Nardostachys jatamansi, and Commiphora mukul were selected and
tested for their efficacy against Aspergillus flavus, A. fumigatus, A.
sulphureus, Mucor fragilis, and Rhizopus stolonifer. These oils were fungistatic
or fungicidal to one or the other molds, depending upon the concentrations.

Publication Types:
Comparative Study

PMID: 749414 [PubMed - indexed for MEDLINE]

15: Arzneimittelforschung. 1978;28(1):7-13.

[Isolation and pharmacodynamic activity of the sesquiterpene valeranone from
Nardostachys jatamansi DC]

[Article in German]

Rucker G, Tautges J, Sieck A, Wenzl H, Graf E.

The known sesquiterpene valeranone (= Yatamanson) was isolated from the
subterranian parts of Nardostachys yatamansi (DC). It was pharmacologically
investigated in animal experiments of sedative, tranquilizing and
antihypertensive properties. In some experiments, typical for tranquilizers,
certain activities could be demonstrated such as the prolongation of barbiturate
hypnosis, the impairment of rotarod performance, an anticonvulsive activity on
electric shock and potentiation of the body-temperature lowering activity of
reserpine. In three other pharmacological models an anti-ulcer action was
detected. In general the activity of valeranone was lower than those of the
standard substances used. As regards the hypotensive property only a weak
activity was demonstrated. In toxicological studies on rats and mice an oral
LD50 of greater than 3160 mg/kg was found, which suggests the possibility of a
therapeutically useful dose ratio.

Publication Types:
English Abstract

PMID: 580202 [PubMed - indexed for MEDLINE]

16: Spec Rep Ser Indian Counc Med Res. 1965;51:1-117.

Nardostachys jatamansi: a chemical, pharmacological and clinical appraisal.

Arora RB.

PMID: 5844450 [PubMed - indexed for MEDLINE]

17: Indian J Physiol Pharmacol. 1963 Jul;7:158-64.

EFFECT OF NARDOSTACHYS JATAMANSI AND RHUS SUCCEDANEA AGAINST HISTAMINE AND
SEROTONIN RESPONSES ON LUNG PERFUSION AND TIDAL AIR CHANGES.

GUPTA SS, SETH CB, BALCHANDANI GH.

PMID: 14117954 [PubMed - OLDMEDLINE]

18: Prensa Med Argent. 1963 Apr 19;50:1021-5.

[PHARMACOLOGY OF JATAMANSIN. ACTIVE SUBSTANCE OF THE PLANT NARDOSTACHYS
JATAMANSI.]

[Article in Spanish]

BISWAS K.

PMID: 14078287 [PubMed - OLDMEDLINE]

19: Indian J Physiol Pharmacol. 1962 Jan;6:27-37.

Effect of Nardostachys jatamansi and Rhus succedanea against constrictor
responses of histamine, acetylcholine and serotonin on smooth muscles.

GUPTA SS, SETH CB, MATHUR VS.

PMID: 13903010 [PubMed - indexed for MEDLINE]

20: J Indian Med Assoc. 1961 Sep 1;37:223-5.

Effect of Nardostachys jatamansi fumes and aerosols in histamine-induced
bronchial asthma in guinea pigs.

GUPTA SS, PATEL CB, MATHUR VS.

PMID: 13903009 [PubMed - OLDMEDLINE]

21: Arch Int Pharmacodyn Ther. 1958 Jan 1;113(3-4):367-76.

Prolonged hypotensive effect of the essential oil of Nardostachys jatamansi.

ARORA RB, SINGH KP, DAS PK, MISTRY PN.

PMID: 13522275 [PubMed - OLDMEDLINE]

22: Indian J Med Sci. 1957 Oct;11(10):803-7.

Nardostachys Jatamansi DC: its sedative and depressant action as estimated by
Warburg technique.

BOSE BC, GUPTA SS, BHATNAGAR JN, VIJAYVARGIYA R.

PMID: 13491086 [PubMed - OLDMEDLINE]

23: Indian J Med Sci. 1957 Oct;11(10):799-802.

Nardostachys Jatamansi DC: a phyto-chemical study of its active constituents.

BOSE BC, VIJAYVARGIYA R, BHATNAGAR JN.

PMID: 13491085 [PubMed - indexed for MEDLINE]

24: Indian J Med Res. 1956 Apr;44(2):259-69.

Antiarrhythmics. III. Antiarrhythmic activity of Nardostachys jatamansi (an
Indian indigenous drug).

ARORA RB, MADAN BR.

PMID: 13331599 [PubMed - OLDMEDLINE]

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